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Ungenügende Schmerzstillung bei Versuchstieren, auch bei Hunden und Primaten

Eine Studie in der Fachzeitschrift 'Laboratory Animals kommt zum Schluss: "...but analgesic administration to ‘large’ laboratory species is still not optimal."

Die Fachzeitschrift 'Laboratory Animals' ist der Frage nachgegangen, ob Versuchstiere nach ihren Operationen wenigstens genügend Schmerzmittel erhalten. Sie kommen zum Schluss, dass dies bis heute nicht der Fall ist, auch nicht bei höheren Säugetieren wie Hunden oder Affen.

Hier die Zusammenfassung:

Reported analgesic administration to rabbits, pigs, sheep, dogs and non-human primates undergoing experimental surgical procedures

C A Coulter, P A Flecknell and C A Richardson 

Comparative Biology Centre, Medical School, Framlington Place, Newcastle University, Newcastle upon Tyne NE2 4HH, UK

Corresponding author: Claire A Richardson. Email: Claire.Richardson@ncl.ac.uk

Reported analgesic use following experimental surgery is low in rodents and there has been little published information on the frequency of analgesic use in other laboratory species. A structured literature review was conducted to examine analgesic administration in larger laboratory animals. The Scirus search engine was used to identify studies published in peer-reviewed journals that reported carrying out experimental surgery on ‘large’ laboratory animals, specifically rabbits, pigs, sheep, dogs and non-human primates. Seventy-four studies between 2000 and 2001 and 75 studies between 2005 and 2006 were included in the review. There was an increase in the reported administration of systemic analgesics to these species from 50% in 2000–2001 to 63% in 2005–2006. When all agents with analgesic properties were considered (systemic analgesics, local anaesthetics and anaesthetics with analgesic components), the proportion of papers that reported some form of analgesic administration to ‘large’ laboratory animals increased from 86% in 2000–2001 to 89% in 2005–2006. Overall rabbits, pigs, sheep, dogs and non-human primates were more likely to receive analgesics following potentially painful experimental procedures than has been reported in laboratory rodents but analgesic administration to ‘large’ laboratory species is still not optimal.

Key Words: Analgesia • pain • species comparison • surgery • refinement

 


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